In a large mixing bowl, whisk together the buttermilk and hot sauce (if using) until well combined. Add the chicken tenderloins, ensuring they are completely submerged in the mixture. Cover the bowl with plastic wrap and refrigerate for at least 1 hour, or up to overnight for maximum tenderness.
In a separate bowl, combine the flour, garlic powder, onion powder, smoked paprika, cayenne pepper, salt, and black pepper. Stir the mixture well to distribute the spices evenly.
Retrieve the marinated chicken from the fridge and allow any excess buttermilk to drip off. Dredge each chicken tender in the prepared flour mixture, pressing lightly for an even coating. Shake off any excess flour and set aside.
In a large, deep skillet or cast-iron pan, heat the vegetable oil over medium-high heat. Aim for 350°F (175°C). Test the oil by sprinkling a tiny pinch of flour into it; if it bubbles up vigorously, it’s ready for frying.
Carefully add the coated chicken tenders to the hot oil, ensuring not to overcrowd the pan. Fry the tenders for about 4-5 minutes on each side, or until golden brown and the internal temperature reaches 165°F (74°C).
Once cooked, transfer the chicken tenders onto a plate lined with paper towels to absorb excess oil.
Serve the hot chicken tenders immediately with your favorite dipping sauces, and garnish with fresh herbs if desired.
Notes
Serve with your favorite dipping sauces and garnish with fresh herbs for presentation.